Learn in a minute: Dopamine Agonist Vs Antagonist (Parkinsons & Nausea)



Dopamine Agonist VS. Antagonist.
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Medicine is a broad and complex topic. Let’s simplify things, as much as possible.⁣⁣
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In Australia, ALL antipsychotic (e.g. olanzapine, haloperidol, quetiapine and risperidone) medicines block dopamine. Additionally, a lot of antiemetics (eg domperidone, haloperidol, prochlorperazine and metoclopramide) are also dopamine ANTAGONIST.⁣
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Notice how haloperidol is listed as an example for both.⁣ ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⁣
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Most Parkinson’s disease medicines work by INCREASING dopamine or acting as dopamine AGONISTS.⁣⁣
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Look at the adverse effects for antipsychotics and antiemetics dopamine antagonist, do you see how they list ESPE such as akathisia and tardive dyskinesia. These are symptoms of Parkinson’s disease. Note: domperidone does not readily cross the blood–brain barrier so EPSE are rare.⁣⁣
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Now, let’s look at the Parkinson’s disease medicines adverse effects. Do you see how nausea and vomiting, confusion, hallucinations and impulse control disorders are listed? Note: domperidone maybe given to help with the emesis.⁣⁣
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There are a lot more examples on how all these interconnect, which we may cover later 😜.⁣⁣ ⁣⁣

In summary, for adverse effects of antipsychotic and antiemetics dopamine antagonists think of Parkinson’s disease. For adverse effects of Parkinson’s disease medicines think of psychosis and emesis.⁣⁣
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source: https://arabsn.net

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